Tuesday, 6 May 2014
Bone marrow on a chip
Bone marrow grown within a device implanted in a mouse resembles natural marrow, researchers reported. The tissue could be explanted whole, inserted into a lab-on-a-chip and maintained in vitro for 7 days. The cultured marrow mimicked tissue responses to radiation toxicity and treatment for exposure normally only observed in vivo.
Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro; Y-S Torisawa et al; Nature Methods AOP doi:10.1038/nmeth.2938