Scientists
have synthesised nanoparticles which efficiently delivered siRNAs to
endothelial cells in vivo and facilitated
silencing of up to five different endothelial genes concurrently. Gene expression in several other cell types
was not significantly affected by the presence of the delivery agent. The nanoparticles, made of
low-molecular-weight polyamines and lipids, reduced target gene expression in
multiple animal models. In lung cancer models,
primary tumour growth and metastases were both reduced.
In vivo endothelial siRNA delivery using
polymeric nanoparticles with low molecular weight; J.E. Dahlman et al, Nature Nanotechnology, DOI:
10.1038/NNANO.2014.84.
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