A multi-stage microfluidic
device separated tumour or leukaemic cells spiked into blood with high
efficiency. A filtration stage removed
cell aggregates and debris. Then a
carefully designed microfluidic channel generated hydrodynamic forces which
focussed the larger cancer cells into the channel centre; smaller blood cells
were separated off. The central fluid component
entered a third steric hindrance region which further purified the rare cells
by their size and mechanical properties.
High-throughput rare cell
separation from blood samples using steric hindrance and inertial microfluidics;
S. Chen et al, Lab on a Chip; DOI: 10.1039/c3lc51384j
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