How cells change nanoparticles

The protein corona surrounding nanoparticles exposed to biological cells changes according to nanoparticle characteristics, cell type and length of exposure, studies show.  These changes alter nanoparticle aggregation, cell membrane affinity, uptake and retention.  Results suggest nanoparticles have an ever-changing biological ‘identity’ as they travel through numerous microenvironments in the body.

Secreted Biomolecules Alter the Biological Identity and Cellular Interactions of Nanoparticles; A. Albanese et al; ACS Nano; DOI: 10.1021/nn4061012 

http://pubs.acs.org/doi/abs/10.1021/nn4061012