Researchers
have mimicked mesenchymal condensation using a cellular self-assembly method to
successfully generate centimetre-sized anatomically-shaped cartilage from human
mesenchymal stem cells. The engineered
tissue was stratified with physiologically relevant values of Young’s modulus
and co-efficient of friction. In vitro
data suggested the method could be used to repair cartilage defects.
Large,
stratified and mechanically functional human cartilage grown in vitro by
mesenchymal condensation, S. Bhumiritana et al, PNAS,
doi/10.1073/pnas.1324050111
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