A new targeted cancer therapy
termed quadrapeutics (after the four components of the therapy) radically
accelerated and improved the effect of combined chemotherapy and radiation in vivo.
Cancer cells self-assembled systemically administered
antibody-functionalized gold nanoparticles and drug-loaded nanocarriers into
intracellular nanoclusters via receptor-mediated endocytosis. Near-infra-red laser pulses heated the gold
nanoparticles generating vapour plasmonic nanobubbles which then exploded,
releasing the drugs from the nanocarriers into the cytoplasm. Subsequently, xray pulses were locally
amplified in the cancer cells through the emission of secondary electrons by
the gold nanoparticles in the nanoclusters.
Nanocluster size and thus effectiveness increased with the cancer
aggressiveness.
On-demand intracellular
amplification of chemoradiation with cancer-specific plasmonic nanobubbles; Ekaterina Y Lukianova-Hleb et al; Nature Medicine; doi:10.1038/nm.3484
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